Distinct gut microbiota composition in pediatric patients with central nervous system (CNS) tumors: A comparative study.

ABSTRACT:

Background

Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children aged 0-14 years. Despite significant efforts, targeted therapies based on identified pathways have not improved survival rates. Research has shown that the gut microbiota (GM) can influence brain tumor cell proliferation, suggesting that the microbiota-gut-brain axis plays a role in CNS cancer. Our study aims to assess whether the GM composition in pediatric CNS tumors exhibits specific characteristics.

Methods

The study included 18 pediatric patients, 9 diagnosed with CNS tumors (CNS tumors group) and 9 with other tumor types (extra-CNS tumors group). Microbial DNA was extracted from stool samples, and 16S DNA libraries were generated and sequenced. GM composition was a

SUBMITTER: Dossena C 

PROVIDER: S-EPMC12121718 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature