Statistical signature of subtle behavioral changes in large-scale assays.

ABSTRACT: The central nervous system can generate various behaviors, including motor responses, which we can observe through video recordings. Recent advances in gene manipulation, automated behavioral acquisition at scale, and machine learning enable us to causally link behaviors to their underlying neural mechanisms. Moreover, in some animals, such as the Drosophila melanogaster larva, this mapping is possible at the unprecedented scale of single neurons, allowing us to identify the neural microcircuits generating particular behaviors. These high-throughput screening efforts, linking the activation or suppression of specific neurons to behavioral patterns in millions of animals, provide a rich dataset to explore the diversity of nervous system responses to the same stimuli. However, important chal

SUBMITTER: Blanc A 

PROVIDER: S-EPMC12121925 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature