Bidirectional genetic links between chronic obstructive pulmonary disease and frailty: Genome-wide association study insights.

ABSTRACT:

Background

Recent research underscores a potential correlation between chronic obstructive pulmonary disease (COPD) and frailty, suggesting a shared genetic foundation. However, specific genetic factors and mechanisms underlying this association remain unclear. This study aimed to explore genetic connections between COPD and frailty using genome-wide association studies to enhance our understanding and improve clinical management and prevention strategies for these conditions.

Method

We utilised summary statistics for genome-wide association studies to examine the genetic correlations between COPD and frailty using linkage disequilibrium score regression. Local genetic correlations were evaluated using the ρ-heritability estimates from summary statistics method. Using the es

SUBMITTER: Yan F 

PROVIDER: S-EPMC12122021 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature