Assessing Causality Between Endocrine, Nutritional, and Metabolic Disease and Pulmonary Tuberculosis: A Mendelian Randomization Study.

ABSTRACT:

Background and aims

Observational studies frequently report co-occurrence between endocrine, nutritional, and metabolic disease (ENMD) and pulmonary tuberculosis (PTB). However, the causal properties between them remain poorly defined. Our aim in this study was to investigate the causal effect of ENMD on PTB using Mendelian randomization analysis.

Methods

We obtained single nucleotide polymorphisms linked to ENMD, ENMD-related diseases, and clinical features, as well as PTB, from the IEU OpenGWAS project. Inverse variance weighting was used as the primary analytical method, complemented by Weighted median and MR-Egger regression to assess their causal relationship. Heterogeneity and horizontal pleiotropy were assessed using Cochran's Q test and MR regression intercepts. The

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12122389 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature