Deciphering the brain glucose metabolism: A gateway to innovative stroke therapies.

ABSTRACT: Stroke is the leading cause of physical disability and death among adults in most Western countries. Consecutive to a vascular occlusion, cells face a brutal reduction in supply of oxygen and glucose and thus an energy failure, which in turn triggers cell death mechanisms. Among brain cells, neurons are the most susceptible to ischemia because of their high metabolic demand and low reservoir of energy substrates. In neurons, glycolysis uses glucose coming from blood or from glycogen stored in astrocytes, underlying the deep astrocyte-neuron metabolic cooperation. During ischemia, both the aerobic and anaerobic pathways and thus energy production are compromised, which disrupts proper cell functioning, notably Na⁺/K⁺ ATPase and mitochondria. This results in altered Ca<

SUBMITTER: Pisani DF 

PROVIDER: S-EPMC12122490 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature