In vitro and in silico evaluation of fluorinated diphenylamine chalcone derivatives as potential antimalarial and anticancer agents.

ABSTRACT: A series of novel diphenylamine fluorinated chalcone derivatives (B1-B10) were synthesized and characterized using ¹H and ¹³C NMR, IR, and MS, and purity was determined using HPLC. The compounds were evaluated for their antimicrobial, antimalarial, and anticancer activities, with Chloramphenicol, Griseofulvin, and 5-Fluorouracil serving as standard reference drugs. Notably, B6 exhibited excellent antifungal activity, comparable to that of the standard drug Griseofulvin. Compounds B3 and B5 showed strong antimalarial effects against Plasmodium falciparum. Both B3 and B5 exhibit substantial cytotoxicity against HeLa cells, with IC₅₀ values of 24.53 µg/ml for B5 and 32.42 µg/ml for B3. These results clearly demonstrate that both compounds outperform the standa

SUBMITTER: Shah A 

PROVIDER: S-EPMC12122917 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature