Machine learning identifies SRD5A3 as a propionate-related prognostic biomarker in triple-negative breast cancer.

ABSTRACT: The increased risk of recurrence and metastasis are obstacles to treating TNBC. Propionate-related genes play an important role in tumor development and immune cell infiltration. The study was to identify the association between propionate-related genes and the prognosis of TNBC patients. Propionate-related genes were collected and analyzed to establish propionate-related gene characteristics. Then, the survival analysis was performed, and the responses to immunotherapies were evaluated. Furthermore, the drug sensitivity of some traditional chemotherapeutic drugs was evaluated. Finally, the hub genes were discovered and validated by in vitro experiments. Based on the five-propionate-related gene signature, TNBC patients were divided into high and low-risk groups. In addition, DEGs between

SUBMITTER: Pan K 

PROVIDER: S-EPMC12122983 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature