Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis.

ABSTRACT:

Objective

Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune-regulatory cells in pain is unknown. Our objective was to identify synovial innate immune cell subsets and pathophysiologic mechanisms associated with worse pain in patients with knee OA.

Methods

Synovial tissue biopsies from 122 patients with mild-to-severe knee OA pain (Knee Injury and OA Outcome Score [KOOS]) were analyzed to identify associations between synovial histopathology and worse pain. We then used spatial transcriptomics and proteomics of synovial tissue microenvironments (n = 32), followed by single-c

SUBMITTER: Philpott HT 

PROVIDER: S-EPMC12123257 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature