Multiomics-based analysis of key genes, metabolites and pathways unveils mechanism associated with social rank in Chickens.

ABSTRACT: Social rank plays a crucial role in shaping physiological, psychological and immune responses in animals. Our previous study found that gut microbes and short-chain fatty acids as well as brain neurotransmitters are involved with the mechanism of social hierarchy. Nevertheless, how these gut and brain metabolites interact to affect the mechanism of social hierarchy in chickens is not yet known. In this study, 40 hens were randomly divided into four groups at the age of 49 days, and social rank of each hen was determined by 6 times according to the feeding competition tests. Then hens ranked 1/2 were named High Social Rank (HSR, n = 8) and hens ranked 9/10 were named Low Social Rank (LSR, n = 8). We use multiomics to explore gut metabolites, neurotransmitters, and brain transcriptome, neuro

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12123347 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature