Understanding Racial Disparities in Prostate Cancer: A Multifaceted Approach.

ABSTRACT: Prostate cancer (PCa) remains a significant public health challenge in the United States, disproportionately affecting African American (AA) men, who face higher incidence rates, more aggressive disease, and elevated mortality compared to Caucasian American (CA) men. This review explores the multifactorial underpinnings of these disparities, integrating genomic, socioeconomic, environmental, and systemic contributors. Genomic analyses reveal that AA men harbor distinct molecular alterations, including higher frequencies of FOXA1, BRAF, and CHD1 mutations, as well as DNA damage repair defects, highlighting the critical need for population-specific precision medicine. Immune-oncologic pathways and stromal interactions within the tumor microenvironment further underscore biological difference

SUBMITTER: Cobbs C 

PROVIDER: S-EPMC12123386 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature