Structural studies of ribosome from an anaerobic Bacteroidetes human pathogen Porphyromonas gingivalis.

ABSTRACT: Porphyromonas gingivalis, an anaerobic pathogen in chronic periodontitis, belongs to the Bacteroidota phylum and is associated with various virulence factors. Its antibiotic-resistant strains and its propensity to form biofilms pose a challenge to effective treatment. To explore therapeutic avenues, we studied the high-resolution cryogenic electron microscope structures of ribosomes from the wild-type P. gingivalis W83 and the macrolide-resistant mutant strain ermΔporN. The structural analysis revealed unique features primarily at the ribosome periphery. Together with the distinctive distribution of ribosomal RNA modifications, these findings offer insights into the therapeutical potential, such as creation of novel therapeutic compounds inhibiting the specific cellular functions of the P.

SUBMITTER: Hiregange DG 

PROVIDER: S-EPMC12123416 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature