New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance.

ABSTRACT:

Importance

Recent studies suggest standard reference intervals for serum free light chains (FLC) are inaccurate and that this problem can only be partially remedied by using separate reference intervals for individuals with impaired kidney function. This decreases the utility of FLC testing in the clinical evaluation and follow-up of plasma cell disorders, particularly affecting the diagnosis of light chain (LC) monoclonal gammopathy of undetermined significance (MGUS).

Objective

To evaluate the distribution of serum FLC and FLC ratios in individuals with preserved kidney function and to propose revised reference intervals and a new definition of LC-MGUS.

Design, setting, and participants

The Iceland Screens, Treats or Prevents Multiple Myeloma (iStopMM) study is a na

SUBMITTER: Einarsson Long T 

PROVIDER: S-EPMC12123532 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature