ITGB3 and associated molecules as critical biomarkers in Cesarean Scar Pregnancy.

ABSTRACT:

Background

Cesarean scar pregnancy (CSP) is a life-threatening condition with a rising incidence in China. The pathogenesis of CSP remains poorly understood, partly due to the limited availability of comprehensive datasets constrained by spatiotemporal factors.

Objective

This study aimed to explore key regulatory molecules and mechanisms involved in CSP through a multi-omics approach.

Methods

Proteomic analysis was performed on decidual and villous tissues from clinical patients (n = 6, including 3 CSP cases and 3 controls). Gene expression datasets (n = 9) were obtained from the GEO and SRA databases. Bioinformatics analyses were conducted using DAVID, Metascape, and STRING, with transcription factor prediction performed via the JASPAR database. Data analysis was con

SUBMITTER: Qu Z 

PROVIDER: S-EPMC12123731 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature