Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer's disease pathology.

ABSTRACT:

Background

Emerging evidence highlights the bidirectional communication between the gut microbiota and the brain, suggesting a potential role for gut dysbiosis in Alzheimer's disease (AD) pathology and cognitive decline. Existing literature on gut microbiota lacks species-level insights. This study investigates gut microbiota alterations in mild cognitive impairment (MCI), focusing on their association with comprehensive AD biomarkers, including amyloid burden, tau pathology, neurodegeneration, and cognitive performance.

Methods

We analyzed fecal samples from 119 individuals with MCI and 320 cognitively normal controls enrolled in the Taiwan Precision Medicine Initiative on Cognitive Impairment and Dementia cohort. Shotgun metagenomic sequencing was conducted with taxonomic

SUBMITTER: Fan KC 

PROVIDER: S-EPMC12123878 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature