The effect of clonal hematopoiesis on long-term outcomes in patients undergoing coronary artery bypass grafting.

ABSTRACT:

Background

Clonal hematopoiesis of indeterminate potential (CHIP), characterized by age-related somatic mutations in hematopoietic stem and progenitor cells, has been identified as a potential risk factor for cardiovascular events and mortality. However, the significance of CHIP in the context of coronary artery bypass grafting (CABG) remains unexplored. We aim to investigate the potential impact of CHIP on long-term outcomes of patients who underwent CABG.

Methods

We conducted a nested case-control study with 497 patients from the randomized Statin Therapy in Cardiac Surgery (STICS) cohort (ClinicalTrials.gov number NCT01573143). CHIP mutations were identified using ultra-deep sequencing of a targeted panel of 23 genes, with a mean depth of coverage of 16,043x. The relation

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC12124002 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature