Elucidating the role of KLRD1 in coronary atherosclerosis: harnessing bioinformatics and machine learning to advance understanding.

ABSTRACT:

Background

Atherosclerosis (AS) is increasingly recognized as a chronic inflammatory disease that significantly compromises vascular health and serves as a major contributor to cardiovascular diseases. KLRD1 is a gene that encodes a protein involved in the immune system, specifically in the function of natural killer (NK) cells.

Methods

KLRD1 was identified as a focal point through an integrative analysis of DEGs across multiple datasets (GSE43292 and GSE9820) from the GEO database, aligned with immune-related gene sets from the ImmPort database. Advanced analytical tools, including Lasso regression and SVM-RFE, were employed to refine our gene selection. We further applied GSEA and GSVA to these gene sets, revealing significant enrichment in immune-related pathways. The rel

SUBMITTER: Liang H 

PROVIDER: S-EPMC12124003 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature