Kaizen: Decomposing cellular images with VQ-VAE.

ABSTRACT: A fundamental problem in cell and tissue biology is finding cells in microscopy images. Traditionally, this detection has been performed by segmenting the pixel intensities. However, these methods struggle to delineate cells in more densely packed micrographs, where local decisions about boundaries are not trivial. Here, we develop a new methodology to decompose microscopy images into individual cells by making object-level decisions. We formulate the segmentation problem as training a flexible factorized representation of the image. To this end, we introduce Kaizen, an approach inspired by predictive coding in the brain that maintains an internal representation of an image while generating object hypotheses over the external image, and keeping the ones that improve the consistency of inte

SUBMITTER: Majoral D 

PROVIDER: S-EPMC12124493 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature