Hyperbaric oxygen therapy alleviates intestinal and brain damage in experimental necrotizing enterocolitis.

ABSTRACT: Necrotizing enterocolitis is the most common gastrointestinal emergency in newborns. Its etiology involves bacterial colonization, enteral formula feeding, and hypoxic-ischemic injury. The pathology of necrotizing enterocolitis is characterized by coagulation necrosis and bacterial overgrowth, with limited preventative methods available. In addition to affecting the intestine, this disease has long-term neurological consequences for survivors. Hyperbaric oxygen therapy, a well-established treatment for soft tissue infections and injuries caused by hypoperfusion, may serve as an alternative approach for necrotizing enterocolitis. In this study, a necrotizing enterocolitis model was developed in newborn Sprague-Dawley rat pups through the administration of a hyperosmolar formula, combined wi

SUBMITTER: Marsico AL 

PROVIDER: S-EPMC12124700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature