Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations.

ABSTRACT:

Background

Glycated hemoglobin (HbA1c) measures the average blood sugar level over the past three months. As a vital biomarker of blood glucose levels, it is used to diagnose Type-2 diabetes mellitus (T2D) and monitor glycemic control. A heritability estimate of 47% to 59% suggests that about half of the variation in HbA1c levels can be attributed to genetic factors. Despite African populations being the most genetically diverse and unique for fine-mapping, there is a paucity of data on the genetic drivers of HbA1c in African individuals. In this study, we performed functional annotation and a Phenome-Wide Association Study (PheWAS) of HbA1c-associated variants in two African populations.

Method

In this study, we utilized summary statistics of the HbA1c GWAS meta-analysis of

SUBMITTER: Soremekun C 

PROVIDER: S-EPMC12124741 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature