Brain-targeted mild hypothermia ameliorates ischemic brain injury and promotes stroke recovery in aged mice.

ABSTRACT: Therapeutic hypothermia represents a highly promising approach for alleviating ischemic brain injury. However, the majority of preclinical studies predominantly rely on reperfusion-based models using young animals, which poorly reflect the clinical situation of elderly stroke patients with limited recanalization. This study sought to bridge these gaps and accelerate the clinical translation of therapeutic hypothermia while elucidating its neuroprotective mechanisms. In aged (18-20 months old) mice with permanent distal middle cerebral artery occlusion, brain-selective mild hypothermia mitigated acute F-actin stress fiber formation and junctional protein degradation in microvascular endothelial cells, thereby effectively reducing blood-brain barrier leakage and infiltration of peripheral in

SUBMITTER: Lyu J 

PROVIDER: S-EPMC12125008 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature