Disruptions in Tiopronin therapy: impacts on clinical outcomes of pediatric cystinuria patients during the COVID-19 pandemic.

ABSTRACT: Cystinuria, characterized by defective renal absorption of cystine causing recurrent nephrolithiasis, demands ongoing management. This study examines the effects of COVID-19-related disruptions in tiopronin availability on the clinical outcomes of pediatric cystinuria patients. This retrospective cohort study analyzed medical records of 11 pediatric patients with cystinuria, followed from 2001 to 2023. Patients were diagnosed using urine microscopy/biochemistry and stone composition analysis. Clinical outcomes, including renal function and stone status, were assessed using serial ultrasonographic evaluations and 24-hour urinary cystine measurements. At diagnosis, the median age was 13 months, and 63.6% were female. Acute kidney injury was observed in 36.4% of patients, with 27.3% requiring

SUBMITTER: Onal HG 

PROVIDER: S-EPMC12125051 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature