Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells.

ABSTRACT: Suppression of human megakaryocytes by dengue virus (DENV) infection significantly reduces the platelet count that eventually leads to thrombocytopenia, severe dengue and death. To understand DENV interactions with megakaryocytes, we investigated the cell cycle in leukemic human megakaryocytic in vitro cell line (MEG-01 cells). Megakaryocytes are known for complex endomitotic cell cycle leading to their polyploidy state. Our study shows that DENV uses these polyploid cells for its replication. Understanding the modulation of DENV-mediated cell cycle regulation in megakaryocytes is therefore highly important. We show that DENV2 (serotype 2) infection significantly modulates cell cycle signaling. Our protein profile microarray data showed significant upregulation of several cell cycle regula

SUBMITTER: Basak S 

PROVIDER: S-EPMC12125297 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature