Comparison of ileus risk in selected second-generation antipsychotics based on FAERS database.

ABSTRACT: Second-generation antipsychotics (SGAs) have been developed as an alternative to the first-generation antipsychotics due to their fewer side effects. However, clinical case reports suggested a connection between SGAs and ileus. The aim of this study is to explore the links between ileus and SGAs via a pharmacovigilance analysis. Adverse event reports from January 1st, 2014 to December 31st, 2023 were collected from the U.S. Food and Drug Administration Adverse Event Reporting System database. The demographic characteristics of cases were summarized to perform descriptive analysis. The reaction outcomes, actions taken with the drug, and onset time of ileus, were also extracted and analyzed. In disproportionality analysis, the algorithms of reporting odds ratio (ROR) and information componen

SUBMITTER: Tan Y 

PROVIDER: S-EPMC12125466 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature