Treatment Outcomes of <i>Mycobacterium avium</i> Complex Pulmonary Disease with a 2-drug Daily Regimen Using Macrolide and Ethambutol.

ABSTRACT:

Background

Limited data exist on the treatment outcomes of a 2-drug daily regimen of macrolide and ethambutol in patients with Mycobacterium avium complex pulmonary disease (MAC-PD).

Methods

An outcome analysis was performed on 108 patients with MAC-PD who underwent at least 12 months of treatment with macrolides and ethambutol. Microbiological responses, antibiotic resistance rates, and recurrence rates linked to the regimen were analyzed.

Results

The median overall treatment duration for 108 patients was 13.2 months (interquartile range 12.1-14.6 months). A total of 72 (67%) patients achieved culture conversion and microbiological cure, with a median time to culture conversion of 1.7 months (interquartile range 1.2-4.0 months). A clinical cure was observed in

SUBMITTER: Im Y 

PROVIDER: S-EPMC12125670 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature