Integrated microbiome and metabolome analysis reveals a novel interplay between gut microbiota and metabolites in differentiated thyroid carcinoma.

ABSTRACT:

Background

Differentiated Thyroid carcinoma (DTC) is the most prevalent endocrine malignancy. The identification of novel biomarkers for thyroid carcinoma is essential for enhancing our understanding of the molecular mechanisms underlying DTC development. Notably, gut microorganisms and their metabolites play a role in the development of DTC, although their influence is modulated by the host's genetic background and environmental factors. Our study aimed to identify and classify gut microbiota and metabolites associated with DTC.

Methods

90 patients with a confirmed diagnosis of DTC and 33 healthy volunteers donated stool samples for our analysis. To examine the gut microbiota, we utilized 16 S rRNA gene sequencing, a technique that allows for the identification and classifi

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12125819 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature