Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.

ABSTRACT: Rab proteins and their effectors facilitate vesicular transport by tethering donor vesicles to their respective target membranes. By using gene trap insertional mutagenesis, we identified Rab9, which mediates late-endosome-to-trans-Golgi-network trafficking, among several candidate host genes whose disruption allowed the survival of Marburg virus-infected cells, suggesting that Rab9 is utilized in Marburg replication. Although Rab9 has not been implicated in human immunodeficiency virus (HIV) replication, previous reports suggested that the late endosome is an initiation site for HIV assembly and that TIP47-dependent trafficking out of the late endosome to the trans-Golgi network facilitates the sorting of HIV Env into virions budding at the plasma membrane. We examined the role of Rab9 in

SUBMITTER: Murray JL 

PROVIDER: S-EPMC1212642 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature