Coexistence of bla_NDM-1, mcr-1 and bla_CTX-M-199 in an ST499 multidrug resistant Klebsiella pneumoniae iIsolate.

ABSTRACT: The coexistence of multiple resistance genes within a single bacterial strain presents a significant public health challenge, as it complicates treatment options and accelerates the spread of multidrug resistance. While the co-occurrence of bla_NDM-1 and mcr-1 genes in Klebsiella pneumoniae (KP) is uncommon, this study reports the biological characterization of a K. pneumoniae isolate, L5151, derived from a patient with diarrhea. This strain carries bla_NDM-1, mcr-1, and bla_CTX-M-199 resistance genes simultaneously. Multilocus sequence typing (MLST) analysis identified the L5151 strain as an ST499 type. Antimicrobial susceptibility testing (AST) was conducted via agar dilution and the broth microdilution procedure. The AST results revealed that L5151 is resis

SUBMITTER: Hu X 

PROVIDER: S-EPMC12126534 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature