Mitochondria regulate inositol triphosphate-mediated Ca²⁺ release triggered by voltage-dependent Ca²⁺ entry in resistance arteries.

ABSTRACT: An increase in cytoplasmic Ca²⁺ concentration activates multiple cellular activities, including cell division, metabolism, growth, contraction and death. In smooth muscle Ca²⁺ entry via voltage-dependent Ca²⁺ channels leads to a relatively uniform increase in cytoplasmic Ca²⁺ levels that facilitates co-ordinated contraction throughout the cell. However certain functions triggered by voltage-dependent Ca²⁺ channels require periodic, pulsatile Ca²⁺ changes. The mechanism by which Ca²⁺ entry through voltage-dependent channels supports both co-ordinated contraction and distinct cellular responses driven by pulsatile Ca²⁺ changes is unclear. Here in intact resistance arteries we show that Ca²⁺ ent

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12126608 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature