Nanoparticle-mediated celastrol ER targeting delivery amplify immunogenic cell death in melanoma.

ABSTRACT:

Introduction

Chemoimmunotherapy, which benefits from the combination of chemotherapy and immunotherapy, has emerged as a promising strategy in cancer treatment. However, effectively inducing a robust immune response remains challenging due to the limited responsiveness across patients. Endoplasmic reticulum (ER) stress is essential for activating intracellular signaling pathways associated with immunogenic cell death (ICD), targeting drugs to ER might enhance ER stress and improve ICD-related immunotherapy.

Objectives

To improve the immune response of Chemoimmunotherapy.

Methods

ER targeting nanoparticles TSE-CEL/NP were constructed to enhance immunogenic cancer cell death. Flow cytometry, confocal microscope, TEM and immunofluorescence were used to evaluate the ER ta

SUBMITTER: Wang F 

PROVIDER: S-EPMC12126697 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature