Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching.

ABSTRACT:

Introduction

Sympathetic hyperinnervation plays an important role in modulating the vascular smooth muscle cell (VSMC) phenotype and vascular diseases, but its role in abdominal aortic aneurysm (AAA) is still unknown.

Objectives

This study aimed to investigate the role of sympathetic hyperinnervation in promoting AAA development and the underlying mechanism involved.

Methods

Western blotting and immunochemical staining were used to detect sympathetic hyperinnervation. We performed sympathetic denervation through coeliac ganglionectomy (CGX) and 6-OHDA administration to understand the role of sympathetic hyperinnervation in AAA and investigated the underlying mechanisms through transcriptome and functional studies. Sema4D knockout (Sema4D^-/-) mice were utili

SUBMITTER: Tang Z 

PROVIDER: S-EPMC12126710 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature