WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis.

ABSTRACT:

Introduction

Acute kidney injury (AKI) is associated with high morbidity and mortality rates. The molecular mechanisms underlying AKI are currently being extensively investigated. WWP2 is an E3 ligase that regulates cell proliferation and differentiation. Whether WWP2 plays a regulatory role in AKI remains to be elucidated.

Objectives

We aimed to investigate the implication of WWP2 in AKI and its underlying mechanism in the present study.

Methods

We utilized renal tissues from patients with AKI and established AKI models in global or tubule-specific knockout (cKO) mice strains to study WWP2's implication in AKI. We also systemically analyzed ubiquitylation omics and proteomics to decipher the underlying mechanism.

Results

In the present study, we found that WWP

SUBMITTER: You R 

PROVIDER: S-EPMC12126736 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature