Genetic and phenotypic associations of frailty with cardiovascular indicators and behavioral characteristics.

ABSTRACT:

Introduction

Frailty Index (FI) is a common measure of frailty, which has been advocated as a routine clinical test by many guidelines. The genetic and phenotypic relationships of FI with cardiovascular indicators (CIs) and behavioral characteristics (BCs) are unclear, which has hampered ability to monitor FI using easily collected data.

Objectives

This study is designed to investigate the genetic and phenotypic associations of frailty with CIs and BCs, and further to construct a model to predict FI.

Method

Genetic relationships of FI with 288 CIs and 90 BCs were assessed by the cross-trait LD score regression (LDSC) and Mendelian randomization (MR). The phenotypic data of these CIs and BCs were integrated with a machine-learning model to predict FI of individuals in

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12126737 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature