The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination.

ABSTRACT:

Background

Regulation of the nuclear factor-kappa B (NF-kB) signaling pathway is a major host homeostatic mechanism for controlling hyper-inflammation or chronic inflammation. Despite extensive research, the regulatory factors of NF-kB signaling required to preserve homeostasis and control inflammatory disorders are not fully understood. Moreover, the role of MARCH2 in chronic inflammation models and the regulation of MARCH2 activation remain to be elucidated.

Methods

We monitored disease severity and mortality in MARCH2^-/- or MARCH2^+/+ mice induced experimental colitis. Susceptibility to DSS-induced experimental colitis was determined by various methods, including Swiss roll assay and fluorescein isothiocyanate (FITC)-dextran treatment, respectively. R

SUBMITTER: Chathuranga K 

PROVIDER: S-EPMC12126869 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature