Decursin, Identified via High-Throughput Chemical Screening, Enhances Plant Disease Resistance via Two Independent Mechanisms.

ABSTRACT: In order to overcome the damage caused by phytopathogens, plants have evolved a complex defence system to protect themselves, such as the two-tiered innate immunity system. Chemical screening has led to the identification of plant immune-priming compounds, which facilitate the functional dissection of the plant immune system and contribute to chemical control for plant diseases. In this study, we identified decursin, a coumarin natural product, through high-throughput screening for activators of the expression of FLG22-INDUCED RECEPTOR KINASE 1 (FRK1). Decursin functions as a typical immune elicitor, triggering early immune responses, including a reactive oxygen species (ROS) burst, MAPK activation, and transcriptional reprogramming of defence genes. A targeted reverse genetic approach ide

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12127108 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature