The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) metastasis is the main cause of poor treatment outcomes and death in nasopharyngeal carcinoma patients. Previously, we reported that centromere protein N (CENPN) is closely related to the pathogenesis, radiotherapy resistance and chemotherapy resistance of nasopharyngeal carcinoma, but the relationship between CENPN and nasopharyngeal carcinoma metastasis and its molecular mechanism are still unclear.

Methods

Two nasopharyngeal carcinoma cell lines with stable CENPN knockdown and overexpression were constructed, and changes in their proliferation, invasion and metastasis capacity were detected. Transcriptome sequencing after CENPN knockdown was performed to screen downstream genes regulated by CENPN. The effects of CENPN on the ubiqu

SUBMITTER: Wang YF 

PROVIDER: S-EPMC12127386 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature