Bilirubin metabolism in early life and respiratory health during preschool age: A combined analysis of two independent birth cohorts.

ABSTRACT:

Background

Bilirubin has antioxidant properties, and elevated levels within the normal range have been associated with improved lung function and decreased risk of asthma in adults, but studies of young children are scarce. Here, we investigate associations between bilirubin in early life and respiratory health endpoints during preschool age in two independent birth cohorts.

Methods

Bilirubin metabolites were assessed at ages 0.5, 1.5, and 6 years in COPSAC₂₀₁₀ (Copenhagen Prospective Studies on Asthma in Childhood 2010) and ages 1, 3, and 6 years in the VDAART (The Vitamin D Antenatal Asthma Reduction Trial) cohort. Meta-analyses were done to summarize the relationship between levels of bilirubin metabolites and asthma, infections, lung function, and allergic sen

SUBMITTER: Kim M 

PROVIDER: S-EPMC12127853 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature