Viral and Immune Risk Factors of HIV Rebound After Interruption of Antiretroviral Therapy.

ABSTRACT:

Background

Identifying risk factors for human immunodeficiency virus (HIV) rebound after treatment interruption is crucial for designing effective remission strategies.

Methods

Peripheral blood mononuclear cells from participants in the Zurich HIV Primary Infection Cohort (ZPHI, n = 73) and ACTG study A5345 (n = 44) were analyzed before antiretroviral therapy (ART) interruption. We measured cell-associated HIV RNA, total HIV DNA, and proviral diversity (env gene). Immune phenotyping was conducted by flow cytometry. Cox proportional hazards (PH) models and penalized Cox PH models with an adaptive LASSO penalty identified risk factors for time to rebound (HIV RNA >1000 copies/mL).

Results

Late ART initiation was associated with higher rebound risk (shorter time to rebou

SUBMITTER: Gianella S 

PROVIDER: S-EPMC12128076 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature