Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study.

ABSTRACT:

Background

Artemisinin partial resistance, mediated by mutations in the Plasmodium falciparum kelch13 gene (k13), rapidly spread in southeast Asia, undermining the antimalarial effectiveness of artemisinin-based combination therapies. k13 mutations have also arisen in Africa, but their rates of increase are not well characterised. We aimed to quantify the selection of k13 mutations in Africa and compare the selection with that in southeast Asia.

Methods

In this modelling study, we investigated k13 mutation allele frequency at 16 sites in Uganda (2016-22) and five sites in southeast Asia (in Cambodia, Thailand, and Viet Nam; 2003-14). The Ugandan data were obtained from annual clinical surveillance studies and the southeast Asian data were obtained from the MalariaGEN Pf7 dat

SUBMITTER: Meier-Scherling CPG 

PROVIDER: S-EPMC12128186 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature