CD94⁺ natural killer cells potentiate pulmonary ischaemia-reperfusion injury.

ABSTRACT:

Background

Pulmonary ischaemia-reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centred natural killer (NK) cells in mediating IRI; however, there are no existing effective therapies for directly targeting NK cells in humans.

Methods

We hypothesised that a depleting anti-CD94 monoclonal antibody (mAb) would provide therapeutic benefit in mouse and human models of IRI based on high levels of KLRD1 (CD94) transcripts in bronchoalveolar lavage samples from lung transplant patients.

Results

We found that CD94 is highly expressed on mouse and human NK cells, with increased expression during IRI. Anti-mouse and anti-human mAbs against CD94 showed effective NK cell depletion in mouse an

SUBMITTER: Tsao T 

PROVIDER: S-EPMC12128193 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature