Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function.

ABSTRACT:

Background

The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair. Cohesin uses ATP hydrolysis to dynamically extrude DNA loops that bring together cis-regulatory elements and thus regulate gene expression. Some DNA loops are anchored by the binding of CTCF insulator proteins which can stall extruding cohesin complexes, however many DNA loops that connect enhancers and promoters lack CTCF and it is unclear how cohesin is stabilized at these cis-regulatory sites. While cohesin has been found to co-purify with a number of proteins, some of which regulate cohesin function, our current knowledge of cohesin activity is in

SUBMITTER: Rittenhouse NL 

PROVIDER: S-EPMC12128382 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature