C-reactive protein and serum amyloid A protein as complementary biomarkers in differentiating viral and bacterial community-acquired pneumonia in children.

ABSTRACT:

Objective

Distinguishing between viral and bacterial community-acquired pneumonia (CAP) in children is crucial for guiding targeted management and antibiotic use. This study aimed to evaluate the efficacy of serum amyloid A protein(SAA) and C-reactive protein (CRP) as biomarkers to differentiate viral from bacterial CAP in children.

Methods

A total of 441 hospitalized children with a confirmed diagnosis of CAP were initially selected. Of these, 206 met the inclusion and exclusion criteria, including 132 cases of viral pneumonia and 74 cases of bacterial pneumonia. Baseline data and clinical characteristics were collected. Respiratory pathogen detection and blood biomarker measurements, including SAA and CRP levels, were completed within 24 h of admission. Receiver operating

SUBMITTER: Cheng J 

PROVIDER: S-EPMC12128512 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature