An assessment of organophosphate ester mixtures and the placental transcriptome.

ABSTRACT: Prenatal exposure to organophosphate ester (OPE) chemicals, commonly used as flame retardants and plasticizers, has been associated with adverse birth outcomes. The placenta is a critical fetal organ and therefore may be involved in pathogenesis of birth outcomes. The goal of this study was to evaluate associations of 10 maternal urinary OPE metabolites, individually and as a mixture, with the placental transcriptome at birth in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Individual OPE metabolites were evaluated for associations with individual genes as well as co-expressed gene modules. Mixtures analysis was conducted using quantile g-computation. The analyses were performed with the entire data set (N = 737) as well as the sex-stra

SUBMITTER: Lapehn S 

PROVIDER: S-EPMC12128679 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature