The Association of Circulating Immune Cells With Cognitive Function, Brain Imaging, and Incident All-cause and Alzheimer's Dementia: The Framingham Offspring Study.

ABSTRACT: Emerging evidence supports the central role of the immune system in brain health, yet little is known about the role of circulating immune cells and cognitive function or brain health in dementia-free populations. We investigated the association of 43 immune cells with cognitive function, structural brain imaging, and incident dementia in Framingham Heart Study Offspring participants. Immune cells were phenotyped by flow cytometry. Linear mixed effects models were used for cross-sectional associations between immune cells and 4 cognitive domain scores and 13 brain magnetic resonance imaging measurements. Cox proportional hazards regression models tested the relationship between immune cells and time to dementia. Models were adjusted for age, sex, education, cytomegalovirus status, and APOE

SUBMITTER: Cao Y 

PROVIDER: S-EPMC12128850 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature