The brain-body circuit mediates acute stress-induced antiinflammatory reflex in bacterial cystitis by suppressing ILC2 activation.

ABSTRACT: Urinary tract infections (UTIs) are one of the most commonly encountered infections in clinical practice, in which psychological stress is a critical pathological contributor to modulate immune function. However, mechanistic pathways linking stress networks in the brain to bladder infection remain poorly understood. In this study, we discovered that acute stress treatment suppressed bladder inflammation in mice with UTIs, and a substantial number of neurons showing overlap between inflammation-associated markers and retrograde labeling were observed in the paraventricular nucleus (PVN) brain region of these mice. Activation of the PVN alleviated uropathogenic Escherichia coli-induced bladder inflammatory response. Moreover, a blocked hypothalamic-pituitary-adrenal axis reversed the antiinf

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12128985 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature