A cross-sectional study of the role of epithelial cell injury in kidney transplant outcomes.

ABSTRACT:

Background

Expression of acute kidney injury-associated (AKI-associated) transcripts in kidney transplants may reflect recent injury and accumulation of epithelial cells in "failed repair" states. We hypothesized that the phenomenon of failed repair could be associated with deterioration and failure in kidney transplants.

Methods

We defined injury-induced transcriptome states in 4,502 kidney transplant biopsies injury-induced gene sets and classifiers previously developed in transplants.

Results

In principal component analysis (PCA), PC1 correlated with both acute and chronic kidney injury and related inflammation and PC2 with time posttransplant. Positive PC3 was a dimension that correlated with epithelial remodeling pathways and anticorrelated with inflammation. Bot

SUBMITTER: Halloran PF 

PROVIDER: S-EPMC12128995 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature