STCC enhances spatial domain detection through consensus clustering of spatial transcriptomics data.

ABSTRACT: The rapid advance of spatially resolved transcriptomics technologies has yielded substantial spatial transcriptomics data. Deriving biological insights from these data poses nontrivial computational and analysis challenges, of which the most fundamental step is spatial domain detection (or spatial clustering). Although a number of tools for spatial domain detection have been proposed in recent years, their performance varies across data sets and experimental platforms. It is thus an important task to take full advantage of different tools to get a more accurate and stable result through consensus strategy. In this work, we developed STCC, a novel consensus clustering framework for spatial transcriptomics data that aggregates outcomes from state-of-the-art tools using a variety of consensus

SUBMITTER: Hu C 

PROVIDER: S-EPMC12129015 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature