Solid Organ Transplant Recipients Exhibit More TET2-Mutant Clonal Hematopoiesis of Indeterminate Potential Not Driven by Increased Transplantation Risk.

ABSTRACT:

Purpose

Solid organ transplant recipients comprise a unique population of immunosuppressed patients with increased risk of malignancy, including hematologic neoplasms. Clonal hematopoiesis of indeterminate potential (CHIP) represents a known risk factor for hematologic malignancy and this study describes the prevalence and patterns of CHIP mutations across several types of solid organ transplants.

Experimental design

We use two national biobank cohorts comprised of >650,000 participants with linked genomic and longitudinal phenotypic data to describe the features of CHIP across 2,610 individuals who received kidney, liver, heart, or lung allografts.

Results

We find individuals with an allograft before their biobank enrollment had an increased prevalence of TET2 mutati

SUBMITTER: Silver AJ 

PROVIDER: S-EPMC12129112 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature