Remote electrical neuromodulation to treat children and adolescents with migraine in the emergency department: A randomized double-dummy pilot trial.

ABSTRACT:

Objective

Using a double-dummy pilot randomized controlled trial design, we aimed to determine the feasibility and acceptability of comparing remote electrical neuromodulation (REN) to typical care intravenous pharmacologic interventions for the treatment of children and adolescents visiting the emergency department (ED) with migraine, and to compare parallel-group versus crossover trial designs.

Background

There are limited data to guide the management of migraine in the ED. Children and adolescents are interested in neuromodulation, and specifically REN, for treatment in this setting, but there are no existing data on this approach.

Methods

We employed a double-dummy, double-blind, pilot randomized controlled trial that tested two designs in two phases: a parallel-g

SUBMITTER: Orr SL 

PROVIDER: S-EPMC12129245 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature