Hypertension and frozen shoulder: A bidirectional 2-sample Mendelian randomization study.

ABSTRACT: Observational studies have demonstrated an association between hypertension and frozen shoulder (FS). However, there is still a lack of clarity about their possible causal relationship. This study aimed to explore whether a genetic relationship exists between hypertension and FS bidirectional through 2-sample Mendelian randomization (MR) analysis. In this study, we investigated the following using data from genome-wide association studies. Exposure-related genetic variants that are independent of each other, were rigorously screened for use as instrumental variables (IVs). To investigate the causal connection, we performed the bidirectional 2-sample MR analysis using these IVs. Inverse-variance weighted (IVW) analysis was the primary method used to analyze the data and augmented by 4 addit

SUBMITTER: Liang M 

PROVIDER: S-EPMC12129497 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature