Causal relationship between distinct sleep characteristics and delirium: A multivariable Mendelian randomization study.

ABSTRACT: Delirium is a common neurological complication among hospitalized patients and has been closely linked to sleep disturbances. Dynamic changes in sleep rhythms are influenced by various sleep characteristics, which complicates the identification of the relationship between individual sleep features and the risk of delirium. Therefore, this study aimed to assess the potential causal relationships between distinct sleep characteristics and delirium, and to further investigate their independent effects. We obtained summary-level data on delirium and 10 distinct sleep characteristics. inverse-variance weighted (IVW) was employed as the primary analytical approach, supplemented by additional robust Mendelian randomization (MR) techniques. To ensure the robustness of the IVW results, heterogeneit

SUBMITTER: Jiang C 

PROVIDER: S-EPMC12129517 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature